Randomized trial evaluates the effect of experimental periodontitis on kidney disease progression, suggesting metabolic links to inflammation.
Key Points
This study aims to determine how experimental periodontitis affects the progression of diabetic kidney disease and its related metabolic pathways.
Induced experimental periodontitis in male db/db mice using silk ligation and Porphyromonas gingivalis administration.
Assessed renal function, histopathology, inflammatory responses, and glycolytic metabolism in vivo.
Performed in vitro experiments in human proximal tubular epithelial (HK-2) cells.
Experimental periodontitis exacerbated kidney dysfunction and renal fibrosis in diabetic mice with no increase in fasting blood glucose levels.
Increased expression of glycolytic-related enzymes and lactate accumulation were noted, alongside decreased ATP levels and altered NAD+/NADH ratios due to periodontitis.
mTOR inhibition partially reduced renal dysfunction, fibrosis, and glycolytic changes associated with experimental periodontitis.