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September 10, 2025Frontiers in ImmunologyOpen Access

Long-term hyperglycaemia exerts contrasting effects on M1- and M2-like macrophages

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Authors

SMSona MargaryanDPDavid PoghosyanSGSusanna Ghonyan

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Overview

In vitro analysis shows hyperglycemia disrupts M1 and M2 macrophage functions, indicating potential links to metabolic disorders.

Key Points

  • Hyperglycemia reduces the function of M1-like macrophages while promoting M2-like macrophages to polarize towards M1.
  • M1 macrophages show diminished production of ROS, IL-6, and TNF-α under prolonged hyperglycemic conditions.
  • Distinct changes in macrophage phenotype under hyperglycemia may contribute to inflammatory responses in metabolic disorders.
  • Increased TNF-α and reduced phagocytosis indicate endotoxin tolerance disturbance in macrophages due to hyperglycemia.

Cite This Study

Margaryan et al. (2025) studied this question.

synapsesocial.com/papers/68c23e4fb210217d64791c67https://doi.org/10.3389/fimmu.2025.1639650
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  5. 5Cellular Abnormalities Induced by High Glucose in Mixed Glial Cultures Are Maintained, Although Glucose Returns to Normal Levels2025