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September 25, 2025Integrative Medicine in Nephrology and Andrology

Hypoxia-Induced Metabolic Reprogramming in the Renal Tubules of Patients with Diabetic Kidney Disease and the Associated Traditional Chinese Medicine Intervention Strategies

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Authors

LJLi JiangXZXueming ZhangXWXiai Wu

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Overview

Observational analysis explores hypoxia-induced metabolic reprogramming in renal tubules of DKD patients, suggesting TCM interventions can mitigate these effects.

Key Points

  • Hypoxia-induced metabolic reprogramming in renal tubules escalates diabetic kidney disease progression, leading to cellular damage.
  • Elevated levels of urinary KIM-1 and NGAL correlate with faster declines in renal function, highlighting tubular injury's role in DKD.
  • Assessment using traditional Chinese medicine interventions shows promise in improving mitochondrial function and reversing metabolic impairments in DKD.
  • Targeting hypoxia and its metabolic consequences presents a novel therapeutic approach to managing diabetic kidney disease.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68d5d0feddad3c16d4636175https://doi.org/10.1097/imna-d-25-00019
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gut microbiota-derived short-chain fatty acids mediate the antifibrotic effects of traditional Chinese medicine in diabetic nephropathy2025
  2. 2Advances in Traditional Chinese Medicine for the Treatment of Diabetic Nephropathy from the Perspective of Glycolipid Metabolism2025
  3. 3Diabetic kidney disease: from pathogenesis to multimodal therapy–current evidence and future directions2025 · 32 citations
  4. 4Mitochondrial metabolism and dynamics in the development of diabetic kidney disease2026
  5. 5Activation of M1 macrophages promotes diabetic kidney disease by modulating glycolysis via HIF-1α-HK2 signaling pathway2025 · 16 citations