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July 11, 2026BMC NephrologyOpen Access

Mechanisms by which macrophage Ltb4r1 mediates tubular epithelial cell injury to facilitate the advancement of diabetic kidney disease

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Authors

WCWenjing CaoQLQingzhen LiuNCNatalia Viktorovna Chebotareva

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Overview

Randomized trial investigates LTB4R1's role in renal injury in diabetic conditions, suggesting novel treatment targets.

Key Points

  • This research aims to understand how LTB4R1 contributes to kidney cell injury in diabetes and the related macrophage activity.
  • Differentiated THP-1 cells into M0, M1, and M2 macrophages to study their effects on HK-2 cells under high glucose conditions.
  • Assessed glucose concentration effects on LTB4R1 expression and apoptosis in renal cells utilizing qPCR and Western blot.
  • Conducted in vivo experiments using AAV-mediated LTB4R1 shRNA in diabetic mice to measure inflammatory responses and gene expression.
  • High glucose increased LTB4R1 levels and apoptosis in HK-2 cells (P < 0.01).
  • M1 macrophages exacerbated HK-2 cell injury, while M2 macrophages provided protective effects (P < 0.01).
  • Silencing LTB4R1 in diabetic mice significantly reduced inflammatory gene expression and apoptosis markers (all P < 0.01).

Cite This Study

Cao et al. (2026) studied this question.

synapsesocial.com/papers/6a51dd5ac18d7f28ca4ffeedhttps://doi.org/10.1186/s12882-026-05158-8
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