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August 15, 2025Open Access

Pro-inflammatory role of granzyme K producing bystander CD8+ T cells in acute myeloid leukemia

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Authors

LALisa AziezNDNicolas DeredecIBIsmaël Boussaid

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Overview

Observation reveals that bystander CD8+ T cells influence inflammation in acute myeloid leukemia, suggesting future intervention possibilities.

Key Points

  • Bystander CD8+ T cells enrich the bone marrow and contribute to a pro-inflammatory environment in AML.
  • These T cells highly express granzyme K and secrete IL-8, which worsens AML pathology without inducing tumor cell death.
  • The study analyzed paired blood and bone marrow samples from AML patients to assess CD8+ T cell function.
  • The findings highlight the need for new therapeutic strategies to counteract pro-inflammatory CD8+ T cells in AML.

Cite This Study

Aziez et al. (2025) studied this question.

synapsesocial.com/papers/68af750c7567bf4f94fedf26https://doi.org/10.1101/2025.08.12.669682
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Acute Myeloid Leukemia microenvironment is defined by ineffective immune surveillance despite the presence of activated, clonally-expanded CD8 T cells with preserved effector function2025
  2. 2Single-cell transcriptional profiling identifies ADGRG1+ CD8 T cells as critical mediators of graft-versus-leukemia effect in AML relapse after haploidentical hematopoietic stem cell transplantation2025
  3. 3Comprehensive profiling of the bone marrow microenvironment reveals an exhausted immune signature associated with tumor burden in Acute Myeloid Leukemia2025
  4. 4Dynamics of leukemic blast and immune cell populations in Acute Myeloid Leukemia2025
  5. 5Gzmk+ CD8 T cells in inflammatory diseases2025