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December 8, 2025Blood

Single-cell transcriptional profiling identifies ADGRG1+ CD8 T cells as critical mediators of graft-versus-leukemia effect in AML relapse after haploidentical hematopoietic stem cell transplantation

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Authors

LYLuxin YangSPShanshan PeiYLYi Luo

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Overview

Single-cell transcriptional profiling reveals functional shifts and communication networks in AML, suggesting strategies for relapse prevention.

Key Points

  • T cell subsets display altered functions during relapsed acute myeloid leukemia, promoting tumor progression.
  • Communication networks between AML cells and T cells are key to understanding graft-versus-leukemia mechanisms.
  • Single-cell transcriptomics established a detailed bone marrow microenvironment in AML relapses, highlighting treatment strategies.
  • Therapeutically targeting dysregulated cytotoxic properties may improve outcomes in post-transplant relapse patients.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e291https://doi.org/10.1182/blood-2025-5870
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Monocyte-T cells crosstalk orchestrates early graft-versus-leukemia immunity in Acute Myeloid Leukemia patients after allogeneic transplantation2025
  2. 2Mega-scale single-cell profiling reveals novel biomarkers associated with acute GvHD after allogeneic hematopoietic stem cell transplantation2025 · 1 citations
  3. 3Dynamics of leukemic blast and immune cell populations in Acute Myeloid Leukemia2025
  4. 4The Acute Myeloid Leukemia microenvironment is defined by ineffective immune surveillance despite the presence of activated, clonally-expanded CD8 T cells with preserved effector function2025
  5. 5Integrative analysis of the interplay between peripheral immune landscape and leukemic blast adaptation in Acute Myeloid Leukemia2025