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December 8, 2025BloodOpen Access

Comprehensive profiling of the bone marrow microenvironment reveals an exhausted immune signature associated with tumor burden in Acute Myeloid Leukemia

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Authors

GCGabriella ChirumboloGTGiusy TespioFZFederico Zingarelli

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Overview

Analysis identifies increased immune checkpoints related to tumor burden in Acute Myeloid Leukemia, suggesting exhaustion in T cells, dendritic cells, and natural killer cells.

Key Points

  • AML is associated with an exhausted immune signature linked to tumor burden, highlighting immune evasion.
  • At diagnosis, AML patients exhibited increased proportions of immune cells such as regulatory T cells and natural killer cells.
  • Assessment using multiparametric flow cytometry revealed the correlation between immune checkpoint expression and leukemia phenotypes.
  • These findings call for further investigations into potential therapeutic targets for immunotherapeutic strategies in AML.

Cite This Study

Chirumbolo et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e574https://doi.org/10.1182/blood-2025-3517
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  4. 4Deciphering the bone marrow inflammatory cytokine network in AML prognosis and immune evasion: A focus on the IL-1A-CCL3/4 axis as a novel therapeutic target2025
  5. 5Immunosuppressive cells in acute myeloid leukemia: mechanisms and therapeutic target2025 · 17 citations