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August 21, 2025Frontiers in ImmunologyOpen Access

Gzmk+ CD8 T cells in inflammatory diseases

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Authors

XCXin CuiPLPeiyun LiuQZQiong Zhan

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Overview

This review reveals the function and mechanisms of Gzmk+ CD8 T cells, suggesting potential therapeutic targets for inflammatory diseases.

Key Points

  • Gzmk+ CD8 T cells play a significant role in inflammatory diseases, potentially guiding new treatment approaches.
  • These cells exhibit unique proinflammatory responses that differ from other cytotoxic T lymphocytes, particularly through granzyme K activity.
  • Analysis through single-cell RNA sequencing has identified distinct functional properties of various CD8 T cell subsets.
  • Understanding Gzmk+ CD8 T cells may open avenues for innovative therapies against chronic inflammatory conditions.

Cite This Study

Cui et al. (2025) studied this question.

synapsesocial.com/papers/68af6d847567bf4f94fea6f2https://doi.org/10.3389/fimmu.2025.1661755
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