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December 8, 2025BloodOpen Access

Dynamics of leukemic blast and immune cell populations in Acute Myeloid Leukemia

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Authors

NINemo IkonenMKMika Kontro

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Overview

Analysis reveals immune cell changes during treatment phases in acute myeloid leukemia, suggesting novel immunotherapy targets.

Key Points

  • Significant changes in immune cell populations observed during acute myeloid leukemia progression.
  • Single-cell RNA sequencing identified distinct cellular compositions across treatment stages in patients' bone marrow.
  • Observational analysis of longitudinal sample sets highlighted the impact of induction chemotherapy on leukemic cell dynamics.
  • Understanding immune cell interactions with leukemia may enable new targeted therapies and immunotherapy enhancements.

Cite This Study

Ikonen et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da00https://doi.org/10.1182/blood-2025-3490
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrative analysis of the interplay between peripheral immune landscape and leukemic blast adaptation in Acute Myeloid Leukemia2025
  2. 2Comprehensive profiling of the bone marrow microenvironment reveals an exhausted immune signature associated with tumor burden in Acute Myeloid Leukemia2025
  3. 3Functional plasma cell signatures mark AML chemotherapy responders: Evidence from immune niche profiling2025
  4. 4The Acute Myeloid Leukemia microenvironment is defined by ineffective immune surveillance despite the presence of activated, clonally-expanded CD8 T cells with preserved effector function2025
  5. 5Longitudinal single-cell spatial proteomics reveals predictive immune and stem cell signatures in Relapsed/Refractory AML2025