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December 8, 2025Blood

The Acute Myeloid Leukemia microenvironment is defined by ineffective immune surveillance despite the presence of activated, clonally-expanded CD8 T cells with preserved effector function

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Authors

CPChad R. PottsRWRobert S. Welner

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Overview

Multi-platform analysis reveals dysfunctional CD8 T cells in AML, suggesting the microenvironment suppresses immune activity.

Key Points

  • To investigate the dynamics of CD8 T cells within the acute myeloid leukemia microenvironment and their immune functionality.
  • Conducted a multi-platform study including high-dimensional proteomics and in vivo modeling.
  • Profiled diagnostic bone marrow samples using mass cytometry from AML patients and healthy donors.
  • Performed single-cell RNA and TCR sequencing on CD8 T cells from AML patients.
  • Observed depletion of naïve T cells and enrichment of terminal effector cells in AML patients.
  • Identified activated transcriptional states in CD8 T cells from patients achieving remission after chemotherapy.
  • Noted extreme clonal dominance in TP53-mutant AML patients, with substantial expansions of specific CD8 T cell clones.

Cite This Study

Potts et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d1dahttps://doi.org/10.1182/blood-2025-770
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comprehensive profiling of the bone marrow microenvironment reveals an exhausted immune signature associated with tumor burden in Acute Myeloid Leukemia2025
  2. 2Dynamics of leukemic blast and immune cell populations in Acute Myeloid Leukemia2025
  3. 3Pro-inflammatory role of granzyme K producing bystander CD8<sup>+</sup> T cells in acute myeloid leukemia2025
  4. 4Integrative analysis of the interplay between peripheral immune landscape and leukemic blast adaptation in Acute Myeloid Leukemia2025
  5. 5Single-cell transcriptomic analysis reveals impaired immune profiles in elderly AML patients2025