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November 28, 2025BJS OpenOpen Access

Timing of antibacterial prophylaxis and surgical site infection rates in clean orthopaedic and cardiac surgery

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Authors

AMArthur J. MorrisSRSally A RobertsNGNikki Grae

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Overview

Prospective analysis reveals optimal timing for antibacterial prophylaxis reduces surgical site infection rates in orthopaedic and cardiac surgery.

Key Points

  • Surgical site infection rates decreased when antibacterial prophylaxis was administered 21–30 min before incision,
  • 66,292 procedures were analyzed for trends in surgical site infection rates related to prophylactic timing.
  • Multivariable analysis indicated a significant increase in SSI risk when prophylaxis was given 51–60 min before incision, with an odds ratio of 1.7.
  • Findings highlight the need for further outcome data to establish guidelines on antibacterial prophylaxis timing for clean surgical procedures.

Cite This Study

Morris et al. (2025) studied this question.

synapsesocial.com/papers/6928f0f9a65b730b9ea79a52https://doi.org/10.1093/bjsopen/zraf120
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