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August 1, 2025British journal of surgery

8 Timing of surgical antibiotic prophylaxis and surgical site infection rates: timing within the hour before incision may not matter

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Authors

AMArthur J. MorrisSRSally RobertsNGNikki Grae

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Overview

Analysis reveals the timing of antibiotic prophylaxis impacts SSI rates in arthroplasty and cardiac surgery, suggesting optimal timing leads to reduced infections.

Key Points

  • The lowest SSI rate was observed for prophylaxis given 1–10 minutes before incision, highlighting timing’s role in reducing infections.
  • Surgical site infection rates were significantly higher for prophylaxis given more than 30 minutes before incision, indicating a critical timeframe.
  • A retrospective analysis of 102,211 procedures showed varying SSI risks based on surgical type and timing of antibiotic administration.
  • Findings point to a need for further data on prophylaxis timing to form firm recommendations for surgical practice.

Cite This Study

Morris et al. (2025) studied this question.

synapsesocial.com/papers/68af409acf1dd9ea359ec76dhttps://doi.org/10.1093/bjs/znaf159.007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Timing of antibacterial prophylaxis and surgical site infection rates in clean orthopaedic and cardiac surgery2025
  2. 223 Duration of surgical antibiotic prophylaxis after cardiac surgery: 24 hours is sufficient2025
  3. 3Impact of the timing of antibiotic prophylaxis on the surgical site infections in patients undergoing elective general surgery2025 · 1 citations
  4. 4Efficacy of Antibiotic Prophlaxis in Preventing Surgical Site Infections: A Review of Current Practices and Emerging Alternatives in General and Plastic Surgery2023
  5. 5Surgical site infection incidence and surgical antibiotic prophylaxis in the ICU patient: a multicenter observational study2026