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August 22, 2025Indian Journal of PharmacologyOpen Access

Impact of the timing of antibiotic prophylaxis on the surgical site infections in patients undergoing elective general surgery

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Authors

ALAayush LakkannaGRGuguloth RajenderYSYashwant Raj Sakaray

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Overview

Interventional study shows reduced surgical site infections with antibiotics given 0–30 min before incision, highlighting optimal timing.

Key Points

  • Significantly lower rates of surgical site infections were observed in Group A compared to Group B, with only 2 cases versus 8 cases respectively.
  • The study involved 127 patients, with a notable P value of 0.03 indicating statistical significance in infection rates.
  • Patients were divided into two groups based on timing of antibiotic administration—0–30 min before incision versus 30–60 min before incision.
  • Placement of intraoperative drains was significantly associated with increased surgical site infections, as indicated by a P value < 0.001.

Cite This Study

Lakkanna et al. (2025) studied this question.

synapsesocial.com/papers/68af706e7567bf4f94febe83https://doi.org/10.4103/ijp.ijp_797_24
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A comparative study of surgical site infections in clean elective surgical procedures with and without antibiotic prophylaxis2025
  2. 2Timing of antibacterial prophylaxis and surgical site infection rates in clean orthopaedic and cardiac surgery2025
  3. 3Efficacy of Antibiotic Prophlaxis in Preventing Surgical Site Infections: A Review of Current Practices and Emerging Alternatives in General and Plastic Surgery2023
  4. 48 Timing of surgical antibiotic prophylaxis and surgical site infection rates: timing within the hour before incision may not matter2025
  5. 5To Study Prevalence and Factors Affecting Surgical Site Infections Among Surgical Gastroenterological Patients at Tertiary Care Premier Teaching Institute of North India2025