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July 26, 2026Journal of Intensive CareOpen Access

Surgical site infection incidence and surgical antibiotic prophylaxis in the ICU patient: a multicenter observational study

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Authors

BPBruno PastèneNCNyl ChemliEDEmmanuel Dudoignon

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Overview

Multicenter observational study finds high surgical site infection rates and issues with antibiotic use in ICU patients, suggesting need for tailored strategies.

Key Points

  • This study aims to evaluate the incidence of surgical site infections and the practices surrounding antibiotic prophylaxis in critically ill patients undergoing surgery.
  • Retrospective multicenter cohort study conducted in five French ICUs from March 2022 to March 2023.
  • Included adult patients (≥18 years) with an ICU stay ≥ 48 hours who underwent surgery during their ICU stay.
  • Used generalized estimating equations to assess the association between antimicrobial spectrum and SSI, adjusting for clustering within centers.
  • Overall surgical site infection incidence was 21% among the 338 included patients.
  • Patients with suspected infection at the time of surgery had an SSI incidence of 37%, compared to 18% in those without such suspicion.
  • Broad-spectrum antimicrobial use was associated with increased SSI risk (OR 3.06; 95% CI 1.63–5.76; P < 0.001) compared to narrow-spectrum antimicrobials.

Cite This Study

Pastène et al. (2026) studied this question.

synapsesocial.com/papers/6a65a91fd3aea3239cd79284https://doi.org/10.1186/s40560-026-00916-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A comparative study of surgical site infections in clean elective surgical procedures with and without antibiotic prophylaxis2025
  2. 2Optimizing Surgical Prophylaxis: An Audit of Antibiotic Use and Guideline Adherence in a Tertiary Care Hospital with Focus on Antimicrobial Stewardship2025
  3. 3A Comprehensive Study on Antibiotic Prophylaxis Practices Across Diverse Surgical Modalities2025
  4. 4Profile and impact of antimicrobial resistance related to surgical site infections after abdominal surgery in a resource-limited country: a prospective observational cohort study2025
  5. 5Scalpels Shadow: Unveiling the Burden of Surgical Site Infection in a Tertiary Care Centre2025