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August 1, 2025British journal of surgery

23 Duration of surgical antibiotic prophylaxis after cardiac surgery: 24 hours is sufficient

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Authors

AMArthur J. MorrisSRSally RobertsNGNikki Grae

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Overview

Analysis shows no difference in surgical site infection rates for 24-h versus 48-h prophylaxis after cardiac surgery, implying 24-h may be sufficient.

Key Points

  • There was no difference in surgical site infection rates following 24-h and 48-h prophylaxis after cardiac surgery, indicating that a shorter duration is adequate.
  • For 17,227 cardiac procedures analyzed, the rates of any site and type of infection were 3.9% for 24-h and 3.6% for 48-h prophylaxis, showing equivalent outcomes.
  • Analysis from the national Surgical Site Infection Improvement Programme over several years confirmed that cefazolin was the main antibiotic used in most cases (97.3%).
  • The study highlights independent risk factors for surgical site infections, which included female sex, obesity, type of procedure, and diabetes, but duration of prophylaxis was not a factor.

Cite This Study

Morris et al. (2025) studied this question.

synapsesocial.com/papers/68af409acf1dd9ea359ec73fhttps://doi.org/10.1093/bjs/znaf159.021
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 18 Timing of surgical antibiotic prophylaxis and surgical site infection rates: timing within the hour before incision may not matter2025
  2. 2Timing of antibacterial prophylaxis and surgical site infection rates in clean orthopaedic and cardiac surgery2025
  3. 3Impact of the timing of antibiotic prophylaxis on the surgical site infections in patients undergoing elective general surgery2025 · 1 citations
  4. 4A comparative study of surgical site infections in clean elective surgical procedures with and without antibiotic prophylaxis2025
  5. 5Length and Type of Antibiotic Prophylaxis for Infection Prevention in Adults Patient in the Cardiac Surgery Intensive Care Unit: A Narrative Review2025 · 6 citations