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July 31, 2025

Exposure to maternal human milk components interacts with infant polygenic risk to predict childhood atopy

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Authors

QDQing DuanZFZhi Yi FangSSSara Stickley

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Overview

Integration of polygenic risk scores with human milk components predicts atopy in infants, suggesting tailored interventions.

Key Points

  • Core findings reveal human milk components affect childhood atopy risk contingent on genetic predisposition.
  • Network analyses indicate a connection between specific microbes and oligosaccharides, related to atopy prevalence.
  • The gradient-boosting model predicts childhood atopy with an AUC of 0.78, showing superior accuracy with combined factors.
  • Insights into gene-milk interactions may lead to personalized strategies for reducing atopy risk in children.

Cite This Study

Duan et al. (2025) studied this question.

synapsesocial.com/papers/689a094be6551bb0af8cf4afhttps://doi.org/10.21203/rs.3.rs-7143108/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Human milk bioactive compounds and allergic and infectious immunological outcomes: A systematic review2025
  2. 2Effects of maternal allergy and supplementation with ω‐3 fatty acid and probiotic on human milk oligosaccharides2025 · 1 citations
  3. 3Impact of early-life human microbiota on the murine host metabolome: insights from a two-generation HMA mouse model and implications for allergic disease2025
  4. 4A-358 Comparison of Immunoregulatory miRNA, Human Milk oligosaccharides (HMO’s) and Gut Microbiomes between Infants Fed with Human Breast Milk Versus Infant Formula2025
  5. 5The human milk microbiome varies by environmental factors and is associated with infant growth: findings from the IMiC Consortium2025 · 1 citations