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October 3, 2025Clinical ChemistryOpen Access

A-358 Comparison of Immunoregulatory miRNA, Human Milk oligosaccharides (HMO’s) and Gut Microbiomes between Infants Fed with Human Breast Milk Versus Infant Formula

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Authors

DSDesai Vidya SripadBRBalamurugan RamadassNGNaga Guhan

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Overview

Exploratory analysis reveals significant differences in gut microbiomes and miRNA levels between infants, suggesting implications for health outcomes.

Key Points

  • Infants fed human breast milk exhibit more diverse gut microbiomes, which can bolster their immune system and lower infection risk.
  • Statistical analysis shows that miRNA concentration is a key factor influencing the composition of gut microbiomes in infants.
  • Random Forest regression highlights that cluster membership and miRNA concentration are strong predictors of bacterial abundance.
  • The study emphasizes the role of HMOs in supporting beneficial gut bacteria while preventing pathogen adherence to the gut lining.

Cite This Study

Sripad et al. (2025) studied this question.

synapsesocial.com/papers/68e040e5a99c246f578b2f82https://doi.org/10.1093/clinchem/hvaf086.342
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