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September 17, 2025BMC MicrobiologyOpen Access

Impact of early-life human microbiota on the murine host metabolome: insights from a two-generation HMA mouse model and implications for allergic disease

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Authors

YJYmke A. de JongRSRana Melisa SerenVMVida Ramšak Marčeta

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Overview

Two-generation HMA mouse model reveals microbiota's influence on metabolome in hosts, suggesting multifaceted allergic predisposition.

Key Points

  • Early-life microbiota significantly impacts the host metabolome, influencing allergic disease patterns over generations.
  • Distinct microbiota profiles were associated with metabolic changes in mouse offspring, including specific lipids and metabolites.
  • The two-generation HMA mouse model effectively mimicked human microbiota interactions, enhancing understanding of allergy risk.
  • Findings suggest that the development of allergic disease may involve complex microbiota-metabolome relationships requiring further exploration.

Cite This Study

Jong et al. (2025) studied this question.

synapsesocial.com/papers/68d42f69713b0b5dfea70e66https://doi.org/10.1186/s12866-025-04321-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Saccharomycetes and Malassezia fungi associate with early-life gut maturation and allergic disease risk in childhood2026 · 1 citations
  2. 2Exposure to maternal human milk components interacts with infant polygenic risk to predict childhood atopy2025
  3. 3Infant gut microbiota and SCFAs mediate the association between early-life human milk microbiota and neurodevelopment2025
  4. 4A model of early-life interactions between the gut microbiome and adaptive immunity provides insights into the ontogeny of immune tolerance.2025
  5. 5Microbiota-mediated metabolic alterations reveal bidirectional regulation of the gut-nose axis in mice with allergic rhinitis2025