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September 19, 2025Open Access

The human milk microbiome varies by environmental factors and is associated with infant growth: findings from the IMiC Consortium

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Authors

MMMelissa B. ManusKFKelsey FehrCSChi-Hung Shu

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Overview

Observational analysis reveals environmental factors influence the human milk microbiome and infant growth outcomes, suggesting health implications for infants in diverse settings.

Key Points

  • Variations in human milk microbiome can influence infant growth and health outcomes, linking the microbiome to environmental factors.
  • 16S rRNA sequencing indicated geographic and seasonal variability in microbial composition of human milk samples collected from diverse regions.
  • Machine learning models highlighted Corynebacterium as a significant predictor of infant growth outcomes across different populations.
  • This research demonstrates the human milk microbiome's role as an ecological system pertinent to infant health in rural and peri-urban settings.

Cite This Study

Manus et al. (2025) studied this question.

synapsesocial.com/papers/68d43809713b0b5dfea7821fhttps://doi.org/10.1101/2025.09.18.25336021
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Composition of the human milk microbiome in the GUSTO cohort is shaped by intrapartum antibiotic prophylaxis and breastfeeding exclusivity.2025
  2. 2Longitudinal Profiling of the Human Milk Microbiome from Birth to 12 Months Reveals Overall Stability and Selective Taxa-Level Variation2025 · 4 citations
  3. 3Host and environmental determinants of human milk oligosaccharides and microbiota in the Lifelines NEXT cohort2025
  4. 4A-358 Comparison of Immunoregulatory miRNA, Human Milk oligosaccharides (HMO’s) and Gut Microbiomes between Infants Fed with Human Breast Milk Versus Infant Formula2025
  5. 5Human milk bioactive compounds and allergic and infectious immunological outcomes: A systematic review2025