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July 29, 2025

Maternal sucrose intake during pregnancy alone disrupts testosterone and allopregnanolone levels in the fetal brain of rats

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Authors

MJMinseon M JungMIMarwa IdrissiYHYen-Nhi Hoang

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Overview

Research demonstrates that maternal high-sucrose diet alters testosterone and allopregnanolone in the fetal brain, suggesting potential impacts on development.

Key Points

  • Maternal sucrose intake did not change body mass or litter size, but increased male offspring percentage.
  • High-sucrose diet significantly elevated testosterone in the fetal nucleus accumbens region.
  • Allopregnanolone levels decreased in the fetal amygdala with maternal high-sucrose diet.
  • Findings highlight the sensitivity of fetal brain steroid levels to maternal diet during pregnancy.

Cite This Study

Jung et al. (2025) studied this question.

synapsesocial.com/papers/689a093fe6551bb0af8cecf2https://doi.org/10.1101/2025.07.21.664469
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