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September 17, 2025Frontiers in NutritionOpen Access

Maternal high-salt intake induces sex-specific liver injury in offspring: integrative transcriptomic and therapeutic investigation

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Authors

XCXiuli ChenRCRui ChenWSWanyu Song

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Overview

This research shows maternal high-salt diet impacts liver health in offspring, indicating potential therapeutic strategies.

Key Points

  • Maternal high-salt diet significantly increases liver weight and hepatocyte size in offspring, especially males.
  • RNA sequencing identified 466 differentially expressed genes in males and 309 in females, indicating sex-specific effects.
  • Connectivity Map analysis revealed potential therapeutic compounds capable of alleviating hepatic injury caused by high salt intake.
  • These findings highlight how maternal nutrition shapes offspring liver health and indicate possible interventions.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68d42f63713b0b5dfea70c2chttps://doi.org/10.3389/fnut.2025.1657934
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