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July 15, 2025

Supplementary Figure 1 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation

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Authors

LMLingjiao MengHWHaotian WuJWJiaxiang Wu

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Overview

Supplementary figure highlights aberrant circRNA expression and NLRP3 activation in esophageal squamous cell carcinoma, suggesting new pathways for therapy.

Key Points

  • Main finding indicates 393 differentially expressed circRNAs in esophageal squamous cell carcinoma compared to normal tissues.
  • Key evidence shows 158 circRNAs were upregulated and 235 downregulated, significantly affecting disease progression.
  • Approach utilized violin plots, volcano plots, and heat maps to visualize circRNA expression in tumor and normal tissues.
  • Significance lies in uncovering the role of circRNA and NLRP3 activation, potentially guiding new treatment strategies.

Cite This Study

Meng et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc6c4https://doi.org/10.1158/0008-5472.29567987
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Supplementary Figure 2 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  2. 2Supplementary Figure 3 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  3. 3Supplementary Figure 4 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  4. 4Data from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  5. 5Supplementary Figure 8 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025