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July 15, 2025

Supplementary Figure 8 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation

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Authors

LMLingjiao MengHWHaotian WuJWJiaxiang Wu

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Overview

Bioinformatics analysis reveals m5C gene expression and immune cell interactions in esophageal squamous cell carcinoma, suggesting a role in disease progression.

Key Points

  • Aberrant m5c genes facilitate the progression of esophageal squamous cell carcinoma via NLRP3 activation.
  • Differential expression of 15 m5C-related genes was observed in ESCC tissues compared to adjacent tissues.
  • Correlation between NSUN2, ALYREF, and YBX1 with immune cell populations was analyzed, showing significant associations.
  • This research highlights the importance of m5C gene activity in cancer immunity, potentially guiding future therapies.

Cite This Study

Meng et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc675https://doi.org/10.1158/0008-5472.29567948
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Supplementary Figure 1 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  2. 2Supplementary Figure 7 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  3. 3Supplementary Figure 3 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  4. 4Supplementary Figure 2 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  5. 5Supplementary Figure 9 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025