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July 15, 2025

Supplementary Figure 2 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation

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Authors

LMLingjiao MengHWHaotian WuJWJiaxiang Wu

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Overview

This research reveals circTMEM45A's role in NLRP3 activation and disease progression in esophageal squamous cell carcinoma, suggesting a novel pathway for intervention.

Key Points

  • Main finding highlights the significant role of circTMEM45A in the inflammatory progression of esophageal squamous cell carcinoma.
  • Evidence from RNA sequencing shows differential expression of circRNAs, including circTMEM45A, in cancerous versus normal tissues.
  • The research utilizes chromosomal localization and secondary structure prediction methods to study circTMEM45A.
  • Understanding circTMEM45A's activation of NLRP3 may open new avenues for therapeutic strategies in esophageal cancer.

Cite This Study

Meng et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc673https://doi.org/10.1158/0008-5472.29567969
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Supplementary Figure 1 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  2. 2Supplementary Figure 3 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  3. 3Supplementary Figure 4 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  4. 4Supplementary Figure 7 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  5. 5Data from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025