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July 15, 2025

Supplementary Figure 4 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation

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Authors

LMLingjiao MengHWHaotian WuJWJiaxiang Wu

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Overview

Validation of circTMEM45A manipulation shows its role in m5C-mediated NLRP3 activation in esophageal squamous cell carcinoma.

Key Points

  • The study reveals circTMEM45A's significant role in the inflammatory progression of esophageal squamous cell carcinoma.
  • Quantitative analyses demonstrate effective overexpression and knockdown of circTMEM45A in multiple cell lines.
  • Using RT-PCR, the expression levels of both circTMEM45A and TMEM45A were measured post-transfection.
  • Understanding circTMEM45A's mechanism may provide new insights for targeting inflammatory pathways in esophageal cancer.

Cite This Study

Meng et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc655https://doi.org/10.1158/0008-5472.29567963
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