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July 15, 2025

Supplementary Figure 3 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation

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Authors

LMLingjiao MengHWHaotian WuJWJiaxiang Wu

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Overview

Analysis reveals circTMEM45A influences prognosis in esophageal squamous cell carcinoma patients, highlighting NLRP3 activation's role.

Key Points

  • circTMEM45A expression correlates significantly with clinical characteristics like tumor size and T stage of esophageal squamous cell carcinoma.
  • Univariate COX regression analysis identifies circTMEM45A as a potential prognostic marker for esophageal squamous cell carcinoma.
  • FISH imaging confirms consistent interpretation of circTMEM45A in ESCC tissues, supporting its clinical relevance.
  • Findings suggest that targeting circTMEM45A may enhance understanding of inflammatory mechanisms in esophageal squamous cell carcinoma.

Cite This Study

Meng et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc666https://doi.org/10.1158/0008-5472.29567966
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Supplementary Figure 4 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  2. 2Supplementary Figure 2 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  3. 3Supplementary Figure 1 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  4. 4Supplementary Figure 5 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  5. 5Data from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025