Findings reveal circTMEM45A activates NLRP3 through m5C modifications in esophageal carcinoma, suggesting inflammatory pathways contribute to cancer progression.
Key Points
MAIN FINDING: CircTMEM45A is linked to inflammatory progression in esophageal carcinoma through NLRP3 activation.
KEY EVIDENCE: m5C modifications on circTMEM45A and NLRP3 were identified via predictive tools and confirmed by RIP assay.
APPROACH: Techniques included predictions from StarBase and m5Cfinder along with experimental assays in KYSE150 cells.
SIGNIFICANCE: Understanding these pathways may help develop targeted therapies for managing esophageal carcinoma progression.