Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 23, 2026Renal FailureOpen Access

Activation of the TGF-β1/HIPK2 signaling pathway exacerbates EMT injury in renal tubular epithelial cells in diabetic kidney disease

View Full Paper
Ask AI
Bookmark
Share

Authors

PYPeiyuan Yang黄黄远航WLWenming Lin

Discussion

Loading...

Member takes

Overview

Randomized trial reveals TGF-β1 and HIPK2 role in worsening kidney damage in diabetic kidney disease, suggesting new treatment avenues.

Key Points

  • This research aims to explore the role of the TGF-β1/HIPK2 signaling pathway in epithelial-to-mesenchymal transition within diabetic kidney disease.
  • Established a DKD-EMT cellular model using human renal tubular epithelial cells (HK-2) with TGF-β1 and high glucose stimulation.
  • Verified findings in both clinical DKD patients and DKD mouse models.
  • Inhibited HIPK2 expression to assess its effects on EMT progression and renal interstitial fibrosis.
  • Inhibition of HIPK2 significantly delayed EMT progression, leading to improved renal interstitial fibrosis.
  • TGF-β1 exposure caused notable EMT changes in HK-2 cells, indicating a strong link between TGF-β1 and pathway activation for DKD.
  • Elevated HIPK2 expression was confirmed in both clinical DKD patients and DKD mouse models.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a61aea0faa9903c51169da1https://doi.org/10.1080/0886022x.2026.2676360
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanism Study on How PTX3 Drives EMT and Fibrosis of RenalTubular Epithelial Cells in Diabetic Kidney Disease by Activating theJNK Pathway2026
  2. 2GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction2026
  3. 3Periodontitis-Aggravated Diabetic Kidney Disease with Altered Glycolysis2026
  4. 4Reduced <scp>FGF9</scp> Leads to Kidney Injury Through Regulating Renal Tubular Epithelial Cell <scp>EMT</scp> in Diabetes2025
  5. 5Activation of M1 macrophages promotes diabetic kidney disease by modulating glycolysis via HIF-1α-HK2 signaling pathway2025 · 16 citations