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September 23, 2025Journal of Cellular and Molecular MedicineOpen Access

Reduced FGF9 Leads to Kidney Injury Through Regulating Renal Tubular Epithelial Cell EMT in Diabetes

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Authors

WCWeiwei ChenCSChengyang SunXZXiaotan Zhang

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Overview

Bioinformatics analysis reveals fgf9's role in diabetic nephropathy, highlighting its potential as a therapeutic target.

Key Points

  • Reduced fgf9 is associated with kidney injury, likely through its role in regulating epithelial-to-mesenchymal transition in diabetic nephropathy.
  • A negative correlation was observed between fgf9 levels and serum creatinine, supporting its connection to renal health.
  • Bioinformatics analysis combined with RNA sequencing identified key genes regulated by fgf9, including tgf-β1 and hif1α, suggesting its influence on renal cellular processes.
  • These findings indicate that fgf9 could serve as both a biomarker and a therapeutic target in managing diabetic nephropathy.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68d43d6f713b0b5dfea7d1bdhttps://doi.org/10.1111/jcmm.70856
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1FGD5-AS1 and Th1/Th2 imbalance in the progression of diabetic nephropathy: evidence from bioinformatic and experimental validation2025
  2. 2Identification and experimental validation of demethylation-related genes in diabetic nephropathy2025
  3. 3Comprehensive bioinformatics and in vivo validation reveal key molecular drivers of diabetic nephropathy progression2025
  4. 4Activation of the TGF-β1/HIPK2 signaling pathway exacerbates EMT injury in renal tubular epithelial cells in diabetic kidney disease2026
  5. 5Single-Cell Maps Reveal Novel Mechanisms of Ferroptosis and Biomarkers in Diabetic Nephropathy2025