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June 27, 2026Interdisciplinary medicineOpen Access

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

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Authors

LYLan YaoXLXianhui LiangBLBingyu Li

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Overview

Randomized trial explores GSK3β's role in early mitochondrial dysfunction in diabetic tubulopathy, suggesting new therapeutic targets.

Key Points

  • This research investigates how GSK3β influences early mitochondrial dysfunction and contributes to diabetic tubulopathy.
  • Examined GSK3β hyperactivation in renal tubules of diabetic kidney disease (DKD) models.
  • Evaluated the effects of GSK3β inhibition using TDZD-8 and genetic silencing on mitochondrial function.
  • Analyzed TFEB nuclear translocation and downstream signaling mechanisms in experimental models.
  • GSK3β overexpression correlated with increased mitochondrial dysfunction in DKD models.
  • GSK3β inhibition using TDZD-8 significantly reduced early mitochondrial dysfunction.
  • Altered mitochondrial morphology and increased reactive oxygen species production were linked to impaired TFEB function.

Cite This Study

Yao et al. (2026) studied this question.

synapsesocial.com/papers/6a3f68a3aea7db3c1953fa45https://doi.org/10.1002/inmd.70148
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mitochondrial metabolism and dynamics in the development of diabetic kidney disease2026
  2. 2Activation of the TGF-β1/HIPK2 signaling pathway exacerbates EMT injury in renal tubular epithelial cells in diabetic kidney disease2026
  3. 3Dual roles of renal tubular mitochondrial Akt1 in protecting against diabetic nephropathy and improving body glucose metabolism2026
  4. 4Mechanism Study on How PTX3 Drives EMT and Fibrosis of RenalTubular Epithelial Cells in Diabetic Kidney Disease by Activating theJNK Pathway2026
  5. 5Role of Nuclear Receptors, Lipid Metabolism, and Mitochondrial Function in the Pathogenesis of Diabetic Kidney Disease2025 · 19 citations