Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
June 14, 2026Biochemia MedicaOpen Access

Myocardial fibrosis and viability: the role of imaging and biomarkers in patients with chronic total occlusion on coronary angiography

View Full Paper
Ask AI
Bookmark
Share

Authors

ŽTŽeljka Dragila TomašićLMLea MaršićAMAnamaria Mikolčić

Discussion

Loading...

Member takes

Overview

Fibrosis limits current viability tests in CTO; leaves optimal non-invasive strategy open for prospective validation.

Key Points

  • This review aims to update the understanding of non-invasive methods for assessing myocardial viability, focusing on the impact of myocardial fibrosis.
  • Incorporated evidence from 76 studies
  • Evaluated various non-invasive imaging modalities for myocardial viability
  • Assessed the role of specific biomarkers related to myocardial fibrosis
  • Imaging modalities differ in sensitivity and specificity for detecting myocardial viability amidst fibrosis.
  • Biomarkers like procollagen type I carboxy-terminal propeptide and galectin-3 provide insights but lack standardized reference ranges.
  • Circulating biomarkers, while promising, remain experimental and need validation in clinical settings before widespread adoption.

Cite This Study

Tomašić et al. (2026) studied this question.

synapsesocial.com/papers/6a2e45adb1cc60ccdea8aa27https://doi.org/10.11613/bm.2026.020503
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of Imaging Modalities in Estimating Myocardial Viability: A Narrative Review2025
  2. 2Viability testing for guiding revascularization in ischemic cardiomyopathy2026
  3. 3Myocardial Remodelling in Aortic Regurgitation: Time to Think Beyond Volumes and Function?2025 · 9 citations
  4. 4THE RELATIONSHIP OF INDICATORS OF ENDOTHELIAL FUNCTION AND MYOCARDIAL FIBROSIS WITH THE SEVERITY OF CORONARY ATHEROSCLEROSIS IN PATIENTS WITH CHRONIC HEART FAILURE WHO HAVE HAD A MYOCARDIAL INFARCTION2025
  5. 5Therapeutic Targets for Myocardial Fibrosis: A Comprehensive Review of Current and Emerging Approaches2025