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September 10, 2025Cardiovascular & Haematological Disorders - Drug Targets

Therapeutic Targets for Myocardial Fibrosis: A Comprehensive Review of Current and Emerging Approaches

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Authors

AWAnkita WalARAnurag RawatRVRakesh Verma

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Overview

Comprehensive review highlights emerging therapeutic targets for myocardial fibrosis, indicating complex treatment needs.

Key Points

  • Myocardial fibrosis significantly contributes to heart failure, highlighting the need for improved treatment strategies.
  • Traditional treatments like RAAS inhibitors and β-blockers provide only symptomatic relief, not halting progression.
  • Therapies targeting molecular pathways such as anti-TGF-β agents and SGLT2 inhibitors show promising results.
  • A multifaceted approach combining various therapies is essential for managing myocardial fibrosis effectively.

Cite This Study

Wal et al. (2025) studied this question.

synapsesocial.com/papers/68c23caeb210217d64789e80https://doi.org/10.2174/011871529x365096250827101044
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rewiring the scar: translational advances in cardiac fibrosis.2025 · 4 citations
  2. 2Targeting Inflammation and Fibrosis in Cardiovascular Disease: Emerging Mechanisms and Therapies2025 · 16 citations
  3. 3Intercellular Targetable Mechanistic Interface for Cardiac Fibrosis2026
  4. 4Targeting inhibition of the inflammatory response: advances in the treatment of myocardial fibrosis with natural medicine and active ingredients2025 · 2 citations
  5. 5Natural Compounds Targeting Profibrotic Signaling Pathways in Myocardial Fibrosis: Signaling Network Regulation and Therapeutic Potential2026