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September 10, 2025European Heart Journal - Cardiovascular ImagingOpen Access

Myocardial Remodelling in Aortic Regurgitation: Time to Think Beyond Volumes and Function?

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Authors

GTGeorge ThorntonMMMichael P. McKennaJBJonathan Bennett

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Overview

This narrative review examines myocardial fibrosis and its role in risk stratification for aortic regurgitation, suggesting a shift from traditional metrics.

Key Points

  • Myocardial fibrosis detected by cardiovascular magnetic resonance predicts clinical outcomes in aortic regurgitation.
  • Studies associate CMR-detected fibrosis with adverse remodelling after valve intervention, affecting patient treatment plans.
  • Current guidelines primarily focus on left ventricular size and ejection fraction, potentially overlooking early myocardial injury.
  • Integrating fibrosis metrics with functional data may identify patients needing earlier interventions to preserve ventricular function.

Cite This Study

Thornton et al. (2025) studied this question.

synapsesocial.com/papers/68c23caeb210217d6478ad32https://doi.org/10.1093/ehjci/jeaf264
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Asymptomatic Aortic Regurgitation: Evolving Imaging Markers and Contemporary Intervention Strategies2026 · 1 citations
  2. 2Cardiac Imaging Predictors of Ventricular Recovery in Pediatric Patients Undergoing Aortic Valve Intervention for Regurgitation2026
  3. 3Relationship between the Left-to-right Ventricular Volume Ratio and Aortic Regurgitation Severity: An Echocardiographic and Cardiac Magnetic Resonance Imaging Study2025 · 1 citations
  4. 4Assessment of chronic aortic regurgitation using end-diastolic flow reversal in the upper descending aorta: diagnostic accuracy and prediction of aortic valve surgery in a prospective echocardiography and cardiac magnetic resonance imaging study2026
  5. 5Myocardial fibrosis and viability: the role of imaging and biomarkers in patients with chronic total occlusion on coronary angiography2026