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September 5, 2025Complex Issues of Cardiovascular DiseasesOpen Access

The Relationship of Indicators of Endothelial Function and Myocardial Fibrosis With the Severity of Coronary Atherosclerosis in Patients With Chronic Heart Failure Who Have Had a Myocardial Infarction

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Authors

YTYu. A. TrusovYSYu. V. ShchukinAZAnna A. Zinkina

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Overview

Observational analysis explores the link between coronary atherosclerosis severity, endothelial dysfunction, and myocardial fibrosis in chronic heart failure patients, indicating significant impact on health.

Key Points

  • Increased severity of coronary atherosclerosis correlates with decreased left ventricular ejection fraction and impaired myocardial function.
  • Findings indicate that higher concentrations of biomarkers like CRP and NT-proBNP are associated with worsening coronary atherosclerosis in patients.
  • Assessment included echocardiographic evaluations and coronary angiography, revealing significant relationships between rupture of the myocardial structure and atherosclerotic burden.
  • These results may help in understanding the mechanisms of chronic heart failure post-myocardial infarction and highlight the role of inflammatory and profibrotic markers.

Cite This Study

Trusov et al. (2025) studied this question.

synapsesocial.com/papers/68c239e5b210217d6477ea71https://doi.org/10.17802/2306-1278-2025-14-4-37-46
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