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June 13, 2026Open Access

Predictive Value of Non-Traditional Lipid Parameters NHHR and the TyG Index for Rapid Kidney Function Decline in Diabetic Patients: A Longitudinal Cohort Study Based on CHARLS

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Authors

PLPeixing LiZLZhu L

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Overview

Longitudinal cohort study investigates NHHR and TyG index as predictors of rapid kidney function decline in diabetic patients, suggesting higher risks.

Key Points

  • This study aims to assess how well NHHR and TyG index can predict rapid kidney function decline in diabetic patients.
  • Used data from China Health and Retirement Longitudinal Study (CHARLS) 2011–2015.
  • Analyzed 1051 patients with diabetes focusing on RKFD as the primary endpoint.
  • Applied logistic regression models, ROC curves, and subgroup analyses to examine associations.
  • 189 individuals (17.98%) developed RKFD during a median follow-up of four years.
  • Both NHHR and TyG index were positively correlated with RKFD risk, with NHHR showing a more stable predictive ability.
  • Subgroup analyses revealed stronger predictive value of NHHR in women and non-smokers.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf57cfaef96ed7f057742https://doi.org/10.1051/bioconf/202623701020/pdf
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