What question did this study set out to answer?

This study aims to assess whether LA-GLS-guided management can enhance atrial function and blood pressure control in hypertensive individuals.

June 12, 2026European Journal of Preventive CardiologyOpen Access

Left atrial global longitudinal strain as an early preventive marker in arterial hypertension

Q: What is the clinical evidence from this study?

Study design: RCT. Population: arterial hypertension (n=120). Intervention: LA-GLS-guided evaluation and targeted interventions vs. standard hypertension management. Primary outcome: Blood pressure control (p=0.04).

View Full Paper

Ask AI

Bookmark

Why the study?

Does LA-GLS-guided preventive management improve atrial function and blood pressure control in adults with untreated or insufficiently controlled hypertension?

Population

120 adults aged 40–65 years with untreated or clinic-based insufficiently controlled hypertension.

Comparison

Standard hypertension management plus… vs Standard hypertension management.

Design

Cohort

Follow-up

12 months

Key result

LA-GLS-guided preventive management improved blood pressure control compared to standard management (80% vs 65%, p=0.04) in adults with hypertension.

Authors

DMD Malidze MNM Noniashvili TCT Chanturia

Discussion

Member takes

Overview

Associated with higher BP control rates; hypothesis-generating and should not yet change practice.

Key Points

This study aims to assess whether LA-GLS-guided management can enhance atrial function and blood pressure control in hypertensive individuals.
Prospective study with adults aged 40–65 years with untreated or insufficiently controlled hypertension (≥140/90 mmHg).
Participants received either standard management or standard management plus LA-GLS–guided evaluation and interventions (n=60 each).
Echocardiography was performed at baseline and 12 months, evaluating LA reservoir strain, left atrial volume, and diastolic indices.
LA-GLS improved significantly in the guided group (−21.0±2.1%; +2.2%) compared to minimal change in the standard group (−19.5±2.6%; +0.5%; p<0.01).
Left atrial volume decreased only in the guided group (−10 mL; p<0.05).
Blood pressure control was achieved in 80% of the guided group compared to 65% of the standard group (p=0.04).

Study Design

Type

RCT (n=120)

Structured PICO

Does LA-GLS-guided preventive management improve atrial function and blood pressure control in adults with untreated or insufficiently controlled hypertension?

Population

120 adults aged 40-65 years with untreated or insufficiently controlled hypertension, followed for 12 months.

Intervention

Standard hypertension management plus LA-GLS–guided evaluation and targeted interventions.

Comparator

Standard hypertension management.

Outcome

Improvement in atrial function (LA-GLS) and blood pressure control at 12 months.surrogate

Main Result

Absolute Event Rate: 80% vs 65%

p-value: p=0.04

Incorporating LA-GLS into the follow-up of hypertensive patients improves atrial function and blood pressure control, potentially reducing the incidence of new-onset atrial fibrillation.

Cite This Study

Malidze et al. (2026) conducted an RCT in arterial hypertension (n=120). LA-GLS-guided evaluation and targeted interventions vs. standard hypertension management was evaluated on Blood pressure control (p=0.04). LA-GLS-guided preventive management improved blood pressure control compared to standard management (80% vs 65%, p=0.04) in adults with hypertension.

synapsesocial.com/papers/6a2bd1056550ea4541ffe85a https://doi.org/10.1093/eurjpc/zwag249.108

View Full Paper

Ask AI

Bookmark

June 12, 2026European Journal of Preventive CardiologyOpen Access

Left atrial global longitudinal strain as an early preventive marker in arterial hypertension

View Full Paper

Ask AI

Bookmark

Why the study?

Does LA-GLS-guided preventive management improve atrial function and blood pressure control in adults with untreated or insufficiently controlled hypertension?

Population

120 adults aged 40–65 years with untreated or clinic-based insufficiently controlled hypertension.

Comparison

Standard hypertension management plus… vs Standard hypertension management.

Design

Cohort

Follow-up

12 months

Key result

LA-GLS-guided preventive management improved blood pressure control compared to standard management (80% vs 65%, p=0.04) in adults with hypertension.

Authors

DMD Malidze MNM Noniashvili TCT Chanturia

Discussion

Member takes

Overview

Associated with higher BP control rates; hypothesis-generating and should not yet change practice.

Key Points

This study aims to assess whether LA-GLS-guided management can enhance atrial function and blood pressure control in hypertensive individuals.
Prospective study with adults aged 40–65 years with untreated or insufficiently controlled hypertension (≥140/90 mmHg).
Participants received either standard management or standard management plus LA-GLS–guided evaluation and interventions (n=60 each).
Echocardiography was performed at baseline and 12 months, evaluating LA reservoir strain, left atrial volume, and diastolic indices.
LA-GLS improved significantly in the guided group (−21.0±2.1%; +2.2%) compared to minimal change in the standard group (−19.5±2.6%; +0.5%; p<0.01).
Left atrial volume decreased only in the guided group (−10 mL; p<0.05).
Blood pressure control was achieved in 80% of the guided group compared to 65% of the standard group (p=0.04).

Study Design

Type

RCT (n=120)

Structured PICO

Does LA-GLS-guided preventive management improve atrial function and blood pressure control in adults with untreated or insufficiently controlled hypertension?

Population

120 adults aged 40-65 years with untreated or insufficiently controlled hypertension, followed for 12 months.

Intervention

Standard hypertension management plus LA-GLS–guided evaluation and targeted interventions.

Comparator

Standard hypertension management.

Outcome

Improvement in atrial function (LA-GLS) and blood pressure control at 12 months.surrogate

Main Result

Absolute Event Rate: 80% vs 65%

p-value: p=0.04

Incorporating LA-GLS into the follow-up of hypertensive patients improves atrial function and blood pressure control, potentially reducing the incidence of new-onset atrial fibrillation.

Cite This Study

synapsesocial.com/papers/6a2bd1056550ea4541ffe85a https://doi.org/10.1093/eurjpc/zwag249.108

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark