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January 9, 2026Reviews in Cardiovascular MedicineOpen Access

Left atrial reservoir strain (LASr) is a sensitive and dynamic measure of atrial function that predicts adverse outcomes in various cardiovascular and systemic conditions.

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Key result

Left atrial reservoir strain (LASr) is a sensitive and dynamic measure of atrial function that predicts adverse outcomes in various cardiovascular and systemic conditions.

Authors

ASAndrea null SonaglioniGNGian Luigi null Nicolosi

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Overview

This narrative review demonstrates the diagnostic value of left atrial reservoir strain in various cardiovascular conditions, suggesting its clinical promise.

Key Points

  • The aim is to elucidate the value of left atrial reservoir strain (LASr) in diagnosing cardiovascular and systemic diseases.
  • Reviewed physiological basis and technical aspects of LASr
  • Explored clinical applications across multiple conditions
  • Analyzed diagnostic and prognostic capabilities of LASr in various diseases
  • LASr is a comprehensive biomarker reflecting left-sided cardiac function
  • Impaired LASr correlates with elevated filling pressures and atrial stiffness
  • Shows utility in predicting outcomes in heart failure, atrial fibrillation, and valvular disease
  • Can detect early atrial impairment in systemic disorders before structural changes occur

PICO

O
Primary Outcome
Left atrial reservoir strain (LASr) predictive value for hospitalization and mortality — HR 0.76 (0.68-0.85), p=<0.001

Main Result

Effect estimate: HR 0.76 (95% CI 0.68-0.85)

p-value: p=<0.001

Limitations

  • Vendor variability in LASr measurements
  • Load-dependent nature of LASr
  • Limited applicability of LASr in atrial fibrillation
  • Absence of universal cut-off values for LASr

Cite This Study

Sonaglioni et al. (2025) studied this question. Left atrial reservoir strain (LASr) is a sensitive and dynamic measure of atrial function that predicts adverse outcomes in various cardiovascular and systemic conditions.

synapsesocial.com/papers/69609564f6dae357db7c142fhttps://doi.org/10.31083/rcm46198
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