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September 18, 2025Journal of Clinical MedicineOpen Access

Global Longitudinal Strain as a Prognostic Biomarker for Asymptomatic Moderate to Severe Aortic Regurgitation with Preserved Ejection Fraction: A Systematic Review and Meta-Analysis

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Authors

MKMyung-Rho KimTSTaha ShaikhSTS. H. Taylor

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Overview

Systematic review finds impaired global longitudinal strain predicts adverse outcomes in asymptomatic aortic regurgitation, suggesting clinical relevance.

Key Points

  • Impaired global longitudinal strain was significantly associated with adverse outcomes in asymptomatic aortic regurgitation.
  • The pooled hazard ratio for impaired global longitudinal strain was 1.359, showing a strong predictive value.
  • This systematic review and meta-analysis followed rigorous PRISMA guidelines and included a total of twelve studies.
  • Findings support the potential for global longitudinal strain to enhance early risk stratification in aortic regurgitation.

Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/68d433b8713b0b5dfea736fahttps://doi.org/10.3390/jcm14186534
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