What does this research mean for the field?

Left atrial strain parameters, particularly peak atrial longitudinal strain and left atrial reservoir strain, exhibit significant diagnostic value and independently predict the risk of new-onset atrial fibrillation. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 6, 2026Frontiers in Cardiovascular MedicineOpen Access

Left atrial strain parameters for predicting new-onset atrial fibrillation: a systematic review and meta-analysis

Q: What is the clinical evidence from this study?

Study design: Meta-Analysis. Population: New-onset atrial fibrillation (NOAF) (n=20681). Intervention: Low peak atrial longitudinal strain (PALS) vs. High peak atrial longitudinal strain (PALS). Primary outcome: New-onset atrial fibrillation (NOAF) (RR 3.95, 95% CI 1.57-9.92, p=0.003).

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Why the study?

Do left atrial strain parameters predict the risk of new-onset atrial fibrillation?

Population

20,681 subjects from 39 cohort, case-control, and cross-sectional studies

Comparison

Left atrial strain parameters including peak… vs Normal or higher levels of left atrial strain…

Design

Meta-analysis

Key result

Low levels of peak atrial longitudinal strain (PALS) were associated with a nearly 4-fold higher risk of new-onset atrial fibrillation (RR 3.95).

Authors

HYHaijian Yang YHYoufu He LPLei Peng

Discussion

Member takes

Overview

May aid early NOAF risk stratification; supports prospective validation before routine clinical adoption.

Key Points

This study aims to assess the predictive value of left atrial strain parameters for new-onset atrial fibrillation (NOAF).
Conducted a systematic review and meta-analysis of studies up to July 30, 2025.
Evaluated the correlation of various left atrial strain parameters with the risk of NOAF.
Used random-effects models to pool risk ratios and conducted sensitivity and meta-regression analyses.
Found significant associations between lower PALS (RR 3.95, 95% CI 1.57–9.92) and higher risk of NOAF.
Meta-analysis yielded pooled AUCs of 0.84 for PALS and LASr, indicating good diagnostic performance.
Each one-unit decrease in PALS, PACS, LASr, LAScd, and LASct was linked to increased NOAF risk (all P < 0.05).

Study Design

Type

Meta-Analysis (n=20,681)

Structured PICO

Do left atrial strain parameters predict the risk of new-onset atrial fibrillation?

Population

20,681 subjects without a known history of atrial fibrillation across 39 studies evaluated for the predictive value of left atrial strain parameters for new-onset atrial fibrillation.

Exposure

Left atrial strain parameters (LASPs) including peak atrial longitudinal strain (PALS), left atrial reservoir strain (LASr), left atrial conduit strain (LAScd), left atrial systolic strain (LASct), and peak atrial contraction strain (PACS) evaluated by speckle tracking echocardiography

Comparator

Normal or higher levels of left atrial strain parameters

Outcome

New-onset atrial fibrillation (NOAF)hard clinical

Main Result

Relative Risk: 3.95 (95% CI 1.57–9.92)

p-value: p=0.003

Left atrial strain parameters, particularly PALS and LASr, demonstrate significant predictive and diagnostic value for identifying patients at risk of new-onset atrial fibrillation.

Limitations

Many eligible studies were retrospective
Considerable heterogeneity in measurement methods for left atrial strain across studies
Potential selection bias from single-center studies
High degrees of heterogeneity among included studies

Cite This Study

Yang et al. (2026) conducted a meta-analysis in New-onset atrial fibrillation (NOAF) (n=20,681). Low peak atrial longitudinal strain (PALS) vs. High peak atrial longitudinal strain (PALS) was evaluated on New-onset atrial fibrillation (NOAF) (RR 3.95, 95% CI 1.57-9.92, p=0.003). Low levels of peak atrial longitudinal strain (PALS) were associated with a nearly 4-fold higher risk of new-onset atrial fibrillation (RR 3.95).

synapsesocial.com/papers/6a23b91b71a5da9775e751d2 https://doi.org/10.3389/fcvm.2026.1745597

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June 6, 2026Frontiers in Cardiovascular MedicineOpen Access

Left atrial strain parameters for predicting new-onset atrial fibrillation: a systematic review and meta-analysis

View Full Paper

Ask AI

Bookmark

Why the study?

Do left atrial strain parameters predict the risk of new-onset atrial fibrillation?

Population

20,681 subjects from 39 cohort, case-control, and cross-sectional studies

Comparison

Left atrial strain parameters including peak… vs Normal or higher levels of left atrial strain…

Design

Meta-analysis

Key result

Low levels of peak atrial longitudinal strain (PALS) were associated with a nearly 4-fold higher risk of new-onset atrial fibrillation (RR 3.95).

Authors

HYHaijian Yang YHYoufu He LPLei Peng

Discussion

Member takes

Overview

May aid early NOAF risk stratification; supports prospective validation before routine clinical adoption.

Key Points

This study aims to assess the predictive value of left atrial strain parameters for new-onset atrial fibrillation (NOAF).
Conducted a systematic review and meta-analysis of studies up to July 30, 2025.
Evaluated the correlation of various left atrial strain parameters with the risk of NOAF.
Used random-effects models to pool risk ratios and conducted sensitivity and meta-regression analyses.
Found significant associations between lower PALS (RR 3.95, 95% CI 1.57–9.92) and higher risk of NOAF.
Meta-analysis yielded pooled AUCs of 0.84 for PALS and LASr, indicating good diagnostic performance.
Each one-unit decrease in PALS, PACS, LASr, LAScd, and LASct was linked to increased NOAF risk (all P < 0.05).

Study Design

Type

Meta-Analysis (n=20,681)

Structured PICO

Do left atrial strain parameters predict the risk of new-onset atrial fibrillation?

Population

20,681 subjects without a known history of atrial fibrillation across 39 studies evaluated for the predictive value of left atrial strain parameters for new-onset atrial fibrillation.

Exposure

Comparator

Normal or higher levels of left atrial strain parameters

Outcome

New-onset atrial fibrillation (NOAF)hard clinical

Main Result

Relative Risk: 3.95 (95% CI 1.57–9.92)

p-value: p=0.003

Left atrial strain parameters, particularly PALS and LASr, demonstrate significant predictive and diagnostic value for identifying patients at risk of new-onset atrial fibrillation.

Limitations

Many eligible studies were retrospective
Considerable heterogeneity in measurement methods for left atrial strain across studies
Potential selection bias from single-center studies
High degrees of heterogeneity among included studies

Cite This Study

synapsesocial.com/papers/6a23b91b71a5da9775e751d2 https://doi.org/10.3389/fcvm.2026.1745597

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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