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June 12, 2026European Journal of Preventive CardiologyOpen Access

Assessment of left atrial function in patients with arterial hypertension, a systematic review and meta-analysis

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Why the study?

Does arterial hypertension alter left atrial mechanics compared to healthy controls?

Population

24 studies including 1802 patients with arterial hypertension and 1161 healthy controls

Comparison

Arterial hypertension (exposure) vs Healthy controls

Design

Meta-analysis

Authors

MKM KouremetiDTD TsartsalisPIP Iliakis

Discussion

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Overview

LA strain impairment may flag early hypertensive cardiac involvement; hypothesis-generating for prognostic assessment.

Key Points

  • This review aims to evaluate left atrial mechanics in patients with arterial hypertension compared to healthy controls.
  • Conducted a systematic literature search in PubMed/MEDLINE, Scopus, and Google Scholar databases until July 2025.
  • Included 24 studies with assessments of left atrial strain parameters via speckle-tracking echocardiography.
  • Final sample comprised 1802 hypertensive patients and 1161 healthy controls.
  • Patients with arterial hypertension showed significant impairment in left atrial reservoir and conduit functions (p<0.001).
  • Increased left atrial contractile function was noted in hypertensive patients (higher LAS-A and LASR-A values; p<0.001).
  • No significant publication bias was detected despite some moderate-to-high heterogeneity in analyses.

Structured PICO

Does arterial hypertension alter left atrial mechanics compared to healthy controls?

P
Population
24 studies including 1802 patients with arterial hypertension and 1161 healthy controls
I
Intervention
Arterial hypertension (exposure)
C
Comparator
Healthy controls
O
Outcome
Left atrial strain parameters (LAS-R, LAS-E, LAS-A, LASR-S, LASR-E, LASR-A) measured via speckle-tracking echocardiographysurrogate

Left atrial strain analysis via speckle-tracking echocardiography identifies significant subclinical LA dysfunction, characterized by impaired reservoir/conduit function and compensatory increased contractile function, in patients with arterial hypertension.

Limitations

  • Moderate-to-high heterogeneity in some analyses

Cite This Study

Kouremeti et al. (2026) studied this question.

synapsesocial.com/papers/6a2bd1386550ea4541ffe936https://doi.org/10.1093/eurjpc/zwag249.003
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