Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
June 7, 2026Diabetes

1419-P: Sex Differences in Cardiac Remodeling in Young Adults with Type 2 Diabetes and Obesity

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Are there sex differences in early cardiac remodeling assessed by CMR in young adults with obesity and Type 2 Diabetes?

Population

37 young adults with obesity, mean age 27±8 years for women and 23±5 years for men, approximately 70% with…

Comparison

Cardiac MRI (Philips 3T) assessment vs Sex differences (females vs. males)

Design

Cross-sectional

Authors

SPSUNGHO PARKYCYe Ji ChoiSRShivani Ramesh

Discussion

Loading...

Member takes

Overview

Young adults with obesity and Type 2 Diabetes exhibit early subclinical structural cardiac remodeling, particularly in LV mass indexed to body surface area, which may precede overt functional impairment.

Key Points

  • The study aims to explore sex differences in cardiac remodeling among young adults with type 2 diabetes and obesity.
  • Young women (n=14) and men (n=23) with obesity and type 2 diabetes were recruited.
  • Participants underwent cardiac MRI to evaluate left and right ventricular function and myocardial tissue characteristics.
  • Z-scores were computed using sex-specific reference values from SCMR to identify significant differences.
  • Females showed deviations in left ventricular (LV) end-systolic volume (Z=1.27) and ejection fraction (Z=-1.00).
  • Both sexes exhibited significant deviations in indexed LV mass (females: Z=-1.62, males: Z=-2.03).
  • Sex differences were noted in right ventricular parameters, though within normal ranges.

Structured PICO

Are there sex differences in early cardiac remodeling assessed by CMR in young adults with obesity and Type 2 Diabetes?

P
Population
37 young adults with obesity (14 women, 23 men), mean age 27±8 years for women and 23±5 years for men, approximately 70% with Type 2 Diabetes.
I
Intervention
Cardiac MRI (Philips 3T) assessment
C
Comparator
Sex differences (females vs. males)
O
Outcome
Left and right ventricular size and global function, LV global strain, aortic flow, and myocardial tissue characterization (native T1 and T2* mapping)surrogate

Young adults with obesity and Type 2 Diabetes exhibit early subclinical structural cardiac remodeling, particularly in LV mass indexed to body surface area, which may precede overt functional impairment.

Cite This Study

PARK et al. (2026) studied this question.

synapsesocial.com/papers/6a250c3b7def13d035e1c3ebhttps://doi.org/10.2337/db26-1419-p
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 11404-P: Obesity Drives Cardiac Hypertrophy while Diabetic Kidney Disease Links to Myocardial Edema and Vascular Stiffness in Young Adults with Type 2 Diabetes2026
  2. 22708-LB: Integrated Cardiovascular Risk Assessment in Young Adults with Type 2 Diabetes: The “YOUNG DIABETES” Program2026
  3. 32939-LB: Delayed Autonomic Recovery during Submaximal Exercise in Youth-Onset Type 2 Diabetes: The Young at Heart Study2026
  4. 41125-OR: Effects of Exercise Training on Cardiovascular Function by Cardiorespiratory Fitness Response in Obesity with and without Type 2 Diabetes2026
  5. 52932-LB: Regional Gray Matter Volume in Youth with Type 2 Diabetes, Obesity Alone, and Lean Controls2026