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June 7, 2026Diabetes

2932-LB: Regional Gray Matter Volume in Youth with Type 2 Diabetes, Obesity Alone, and Lean Controls

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Why the study?

Does youth-onset obesity and type 2 diabetes associate with reduced regional gray matter volume compared to lean controls?

Population

158 youth participants across three groups: youth with obesity and type 2 diabetes, obesity alone, and lean…

Design

Cross-sectional

Authors

RBRYAN BRADYASAmy ShahMAMekibib Altaye

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Overview

Youth-onset obesity is associated with reduced gray matter volume, and comorbid type 2 diabetes confers an even greater detrimental effect on brain volume in adolescence.

Key Points

  • This study aims to investigate the differences in regional gray matter volume among youth with type 2 diabetes, obesity, and lean controls.
  • Magnetic resonance imaging (MRI) was performed on 158 participants grouped by T2D, obesity only, and lean controls.
  • Comparative analysis of regional gray matter volume focused on group differences using voxelwise significance.
  • Adjustments were made for age, sex, household income, and total intracranial volume.
  • Significant differences in gray matter volume were observed among the three groups of youth.
  • A stepwise decrease in gray matter volume was found, with T2D showing the lowest and lean controls the highest.
  • Results indicate that type 2 diabetes may have an additional detrimental impact on gray matter volume compared to obesity alone.

Structured PICO

Does youth-onset obesity and type 2 diabetes associate with reduced regional gray matter volume compared to lean controls?

P
Population
158 youth participants across three groups: youth with obesity and type 2 diabetes (n=50, 72% female, 16.9 ± 1.8 yrs), obesity alone (n=53, 68% female, 16.1 ± 1.7 yrs), and lean controls (n=55, 56% female, 16.3 ± 2.1 yrs).
O
Outcome
Group differences in regional gray matter volume (GMV) evaluated at a family-wise error-corrected α=0.05surrogate

Youth-onset obesity is associated with reduced gray matter volume, and comorbid type 2 diabetes confers an even greater detrimental effect on brain volume in adolescence.

Cite This Study

BRADY et al. (2026) studied this question.

synapsesocial.com/papers/6a250b2d7def13d035e1b358https://doi.org/10.2337/db26-2932-lb
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Also Consider

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  1. 11419-P: Sex Differences in Cardiac Remodeling in Young Adults with Type 2 Diabetes and Obesity2026
  2. 22070-P: Adiposity Distribution and Emerging Diabetes Risk in Children2026
  3. 32599-P: Increased Regional and Ectopic Adiposity Is Associated with Low Cerebral Blood Flow among Older Adults2026
  4. 4Neurocognitive and Behavioral Outcomes in Patients With Insulin Resistance and Type 2 Diabetes: A Systematic Review of Recent Evidence2025 · 1 citations
  5. 5Structural and Functional Brain Changes in Children and Adolescents With Obesity2025 · 8 citations