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June 7, 2026Diabetes

Subclinical atherosclerosis was identified in 31% of participants; in multivariate analysis, diabetes duration (OR 1.09 [1.01-1.17]) and smoking exposure (OR 1.04 [1.00-1.07]) were independently associated with greater plaque burden.

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Population

179 young adults with type 2 diabetes diagnosed at ≤50 years and current age ≤55 years enrolled in the YOUNG…

Design

Cross-sectional

Authors

MMManel Mateu-SalatABAntonio‐Jesús Blanco‐CarrascoAAAlessandro Atzeni

Discussion

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Overview

In young adults with early-onset type 2 diabetes, subclinical atherosclerosis is common and independently associated with longer diabetes duration and smoking exposure, highlighting the need for early risk factor management.

Key Points

  • This study aims to characterize cardiovascular risk and detect subclinical atherosclerosis in young adults with type 2 diabetes.
  • Observational study involving young adults with type 2 diabetes diagnosed at ≤50 years.
  • Participants underwent clinical assessments, biochemistry tests, and carotid ultrasound for atherosclerosis detection.
  • SCORE2-Diabetes was used for estimating cardiovascular risk in participants.
  • 179 participants were included; median age was 45 years and median diabetes duration was 4 years.
  • Subclinical atherosclerosis detected in 31% of participants who underwent carotid ultrasound, with plaque burden associated with longer diabetes duration and smoking exposure.
  • No significant differences were found based on sex, smoking status, BMI, lipid profile, or calculated CV risk.

Structured PICO

P
Population
179 young adults with type 2 diabetes diagnosed at ≤50 years and current age ≤55 years enrolled in the YOUNG DIABETES clinical program, median age 45 years, 37% women.
O
Outcome
Presence of subclinical atherosclerosis detected by carotid ultrasoundsurrogate

In young adults with early-onset type 2 diabetes, subclinical atherosclerosis is common and independently associated with longer diabetes duration and smoking exposure, highlighting the need for early risk factor management.

Cite This Study

Mateu-Salat et al. (2026) studied this question.

synapsesocial.com/papers/6a250baa7def13d035e1bb47https://doi.org/10.2337/db26-2708-lb
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 11404-P: Obesity Drives Cardiac Hypertrophy while Diabetic Kidney Disease Links to Myocardial Edema and Vascular Stiffness in Young Adults with Type 2 Diabetes2026
  2. 22401-P: Genetic Regulation of Molecular Traits Enhances Precision Risk Stratification in Youth-Onset Type 2 Diabetes2026
  3. 31419-P: Sex Differences in Cardiac Remodeling in Young Adults with Type 2 Diabetes and Obesity2026
  4. 42965-LB: Cardiovascular Disease Risk Prediction in Type 1 Diabetes over 30 Years2026
  5. 52961-LB: Double Diabetes: A Mediator of Age-Related Cardiovascular Risk in Type 1 Diabetes: A Mediation Analysis of a Large T1D Cohort2026