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June 7, 2026Diabetes

Significant Exercise × Responder interactions across the groups were observed for max workload (P < 0.001, η² = 0.31) and ejection fraction (P = 0.013, η² = 0.17).

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Why the study?

Does 15-week supervised aerobic exercise training alter cardiometabolic measures differently based on cardiorespiratory fitness response in adults with obesity with and without T2D?

Population

36 adults with obesity (39% with T2D)

Comparison

15-week supervised aerobic exercise training (AET) vs Non-responders (changes in peak VO2 after AET ≤ 0)

Design

Cohort

Follow-up

15 weeks

Authors

SPSungho ParkEEERIN K. ENGLUNDLKLESLIE KNAUB

Discussion

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Overview

A 15-week supervised aerobic exercise training program elicits heterogeneous physiological adaptations in adults with obesity, with significant differences in max workload and ejection fraction between peak VO2 responders and non-responders.

Structured PICO

Does 15-week supervised aerobic exercise training alter cardiometabolic measures differently based on cardiorespiratory fitness response in adults with obesity with and without T2D?

P
Population
36 adults with obesity (39% with T2D)
I
Intervention
15-week supervised aerobic exercise training (AET)
C
Comparator
Non-responders (changes in peak VO2 after AET ≤ 0)
O
Outcome
Changes in cardiometabolic measures (metabolic biomarkers, echocardiography, and cardiac magnetic resonance imaging)surrogate

A 15-week supervised aerobic exercise training program elicits heterogeneous physiological adaptations in adults with obesity, with significant differences in max workload and ejection fraction between peak VO2 responders and non-responders.

Cite This Study

Park et al. (2026) studied this question.

synapsesocial.com/papers/6a250ce97def13d035e1d191https://doi.org/10.2337/db26-1125-or
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 11419-P: Sex Differences in Cardiac Remodeling in Young Adults with Type 2 Diabetes and Obesity2026
  2. 2Exercise Interventions for Metabolic Diseases: An Analysis of the Evolution of Aerobic Exercise Bibliometrics in the Field of Type 2 Diabetes Mellitus2025 · 1 citations
  3. 3The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes2001 · 488 citations
  4. 42939-LB: Delayed Autonomic Recovery during Submaximal Exercise in Youth-Onset Type 2 Diabetes: The Young at Heart Study2026
  5. 51404-P: Obesity Drives Cardiac Hypertrophy while Diabetic Kidney Disease Links to Myocardial Edema and Vascular Stiffness in Young Adults with Type 2 Diabetes2026