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June 6, 2026Frontiers in PharmacologyOpen Access

Qitu qushi formula ameliorates diabetic kidney disease potentially through gut microbiota-derived indole-3-propionic Acid–Mediated regulation of the Sirt1/FoxO1 pathway

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Authors

LWLiu WJCJunhui ChenWGWenhua Gu

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Overview

Randomized trial shows Qitu Qushi Formula improves diabetic kidney disease in patients, suggesting a gut microbiota pathway's role.

Key Points

  • This study aims to clarify how Qitu Qushi Formula alleviates diabetic kidney disease through gut microbiota.
  • Clinical samples from 30 patients with type 2 DKD evaluated before and after 6 months of QTQSF treatment.
  • Animal studies using db/db mice and fecal microbiota transplantation explored microbiota-mediated effects.
  • Multi-omics analyses, including 16S rRNA sequencing and transcriptomics, investigated underlying pathways.
  • QTQSF significantly improved renal function and gut microbiota composition in T2 DKD patients.
  • In db/db mice, QTQSF reduced albuminuria and apoptosis, effects reduced after gut microbiota depletion.
  • Increased levels of indole-3-propionic acid correlated with regulation of the Sirt1/FoxO1 pathway, improving anti-apoptotic effects.

Cite This Study

W et al. (2026) studied this question.

synapsesocial.com/papers/6a23b86b71a5da9775e7498bhttps://doi.org/10.3389/fphar.2026.1802567
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