Effect and Mechanism of Qihua Tongtiao Formula (QHTTF) on Improving Glucose and Lipid Metabolism Disorders in ZDF Rats by Integrating Network Pharmacology, Metabolomics, and Biological Validation
This analysis finds Qihua Tongtiao Formula significantly lowers glucose and lipid levels in ZDF rats, indicating its potential in managing metabolic disorders.
Key Points
Qihua Tongtiao Formula significantly lowers blood glucose and lipid levels in ZDF rats, improving metabolic disorders.
A total of 39 chemical components were identified, with 59 intersection targets linked to glycolipid metabolism highlighted.
The study employed network pharmacology, metabolomics, and biological validation to explore the mechanisms behind QHTTF's efficacy.
This research suggests QHTTF may alleviate insulin resistance and inflammation while enhancing target protein expressions in ZDF rats.