What does this research mean for the field?

Tiaoqi Daozhi Decoction alleviates irritable bowel syndrome with constipation by modulating the immune-neuro-epithelial network and activating the VIP-PKA-AQP3 signaling pathway to improve intestinal motility and water transport. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To determine the molecular mechanisms and target pathways of Tiaoqi Daozhi Decoction (TQD) in treating irritable bowel syndrome with constipation (IBS-C).

August 26, 2026Journal of Radiation Research and Applied SciencesOpen Access

Multi-omics and machine learning uncover anti-IBS-C mechanism of Tiaoqi Daozhi decoction via immune-neuro-epithelial remodeling and VIP–PKA–AQP3 axis activation

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Authors

LHLixia Huang YXYingyue Xu HYHuang Ya

Discussion

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Overview

Multi-omics and preclinical study demonstrates Tiaoqi Daozhi Decoction relieves IBS-C in a rat model, indicating therapeutic action through VIP-PKA-AQP3 axis activation and immune-neural remodeling.

Key Points

To determine the molecular mechanisms and target pathways of Tiaoqi Daozhi Decoction (TQD) in treating irritable bowel syndrome with constipation (IBS-C).
Screened bioactive components and targets using TCMSP, SwissTargetPrediction, and the GSE146853 IBS-C dataset.
Identified signature biomarkers and compound-target interactions using machine learning, protein-protein interaction networks, molecular docking, and molecular dynamics simulations.
Evaluated therapeutic efficacy and colonic VIP-PKA-AQP3 signaling in a liver-depression syndrome IBS-C rat model.
Identified 74 bioactive constituents and 23 targets, with machine learning designating CETP, SELP, and BTK as core signature genes (AUC = 0.714–0.829).
Confirmed stable binding affinity of isodalbergin to CETP and hyndarin to BTK through molecular docking and dynamic simulations.
Demonstrated that TQD ameliorated depressive-like behaviors and gut motility dysfunction in rats, while significantly increasing colonic VIP, p-PKA/PKA ratio, and AQP3 expression.

Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/6a8e9b34451774b83f3b3cbd https://doi.org/10.1016/j.jrras.2026.102630

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August 26, 2026Journal of Radiation Research and Applied SciencesOpen Access

Multi-omics and machine learning uncover anti-IBS-C mechanism of Tiaoqi Daozhi decoction via immune-neuro-epithelial remodeling and VIP–PKA–AQP3 axis activation

View Full Paper

Ask AI

Bookmark

Authors

LHLixia Huang YXYingyue Xu HYHuang Ya

Discussion

Member takes

Overview

Multi-omics and preclinical study demonstrates Tiaoqi Daozhi Decoction relieves IBS-C in a rat model, indicating therapeutic action through VIP-PKA-AQP3 axis activation and immune-neural remodeling.

Key Points

To determine the molecular mechanisms and target pathways of Tiaoqi Daozhi Decoction (TQD) in treating irritable bowel syndrome with constipation (IBS-C).
Screened bioactive components and targets using TCMSP, SwissTargetPrediction, and the GSE146853 IBS-C dataset.
Identified signature biomarkers and compound-target interactions using machine learning, protein-protein interaction networks, molecular docking, and molecular dynamics simulations.
Evaluated therapeutic efficacy and colonic VIP-PKA-AQP3 signaling in a liver-depression syndrome IBS-C rat model.
Identified 74 bioactive constituents and 23 targets, with machine learning designating CETP, SELP, and BTK as core signature genes (AUC = 0.714–0.829).
Confirmed stable binding affinity of isodalbergin to CETP and hyndarin to BTK through molecular docking and dynamic simulations.
Demonstrated that TQD ameliorated depressive-like behaviors and gut motility dysfunction in rats, while significantly increasing colonic VIP, p-PKA/PKA ratio, and AQP3 expression.

Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/6a8e9b34451774b83f3b3cbd https://doi.org/10.1016/j.jrras.2026.102630

View Full Paper

Ask AI

Bookmark