Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 30, 2026Journal of Clinical Oncology

Conditioning intensity and post-transplant outcomes in acute myeloid leukemia: A real-world analysis.

View Full Paper
Ask AI
Bookmark
Share

Authors

AKAstha Koolwal KapoorYAYanal AlnimerNLNicole Lisek

Discussion

Loading...

Member takes

Overview

Retrospective analysis shows conditioning intensity does not affect relapse timing in AML patients, supporting risk-adapted strategies.

Key Points

  • This analysis aims to evaluate the impact of conditioning intensity on post-transplant outcomes in patients with acute myeloid leukemia (AML).
  • Performed a retrospective analysis of adult AML patients who underwent allogeneic hematopoietic cell transplantation at the University of Kentucky between Jan 2015 and Jan 2025.
  • Collected data on demographics, disease characteristics, ELN risk classification, conditioning types, and transplant outcomes.
  • Calculated overall survival from transplantation and assessed relapse outcomes longitudinally.
  • Total of 147 patients included with a median age of 57 years; 32% received myeloablative conditioning, 53% reduced-intensity.
  • Post-transplant relapse occurred in 32% of patients; median time to relapse was not reached for either group with p=0.6.
  • No significant difference in relapse timing regardless of conditioning type, supporting risk-adapted approaches.

Cite This Study

Kapoor et al. (2026) studied this question.

synapsesocial.com/papers/6a1a7fef0307b785094320b9https://doi.org/10.1200/jco.2026.44.16_suppl.e18573
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Conditioning intensity in myelodysplastic patients aged ≥ 50 years undergoing allogeneic hematopoietic cell transplantation (allo-HCT): a study on behalf of the chronic malignancies working party of the EBMT2025 · 2 citations
  2. 2Outcomes of myeloablative vs reduced and non-myeloablative conditioning in MRD-negative AML and ALL with ptcy-based GVHD prophylaxis2025
  3. 3Impact of conditioning regimen on outcomes of adolescents and young adults AML patients undergoing HCT in complete remission, with transplant conditioning intensity score of 3.5-4.0. a study from the acute leukemia working party of the european society for blood and marrow transplantation.2025 · 1 citations
  4. 4Impact of recipient sociodemographic factors on allogeneic transplant conditioning intensity and survival outcomes in myeloid malignancies: A secondary analysis of CIBMTR data2025
  5. 5Conditioning regimens in pediatric myeloid malignancies undergoing allogeneic HSCT: a comparative single-center study2025 · 2 citations