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December 8, 2025Blood

Outcomes of myeloablative vs reduced and non-myeloablative conditioning in MRD-negative AML and ALL with ptcy-based GVHD prophylaxis

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Authors

WOWilliam O’HaraUGUsama Gergis

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Overview

Retrospective analysis reveals comparable survival in MRD-negative AML and ALL with myeloablative or non-myeloablative conditioning, suggesting lower toxicity with NMA.

Key Points

  • Survival rates at 1 year were similar between myeloablative and non-myeloablative conditioning, both above 75%.
  • Graft-versus-host disease rates were comparable across conditioning groups, indicating similar safety profiles.
  • Overall survival at 4 years was reported at 73.8%, showing consistent outcomes across AML and ALL patients.
  • The study highlights potential advantages of non-myeloablative conditioning, which may be a viable alternative due to reduced toxicity.

Cite This Study

O’Hara et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dd05https://doi.org/10.1182/blood-2025-7716
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Conditioning intensity and post-transplant outcomes in acute myeloid leukemia: A real-world analysis.2026
  2. 2Allogeneic hematopoietic stem cell transplantation for hematological malignancies using nonmyeloablative fludarabine, cyclophosphamide, 200 centigray total body irradiation, and post-transplant cyclophosphamide, sirolimus, and mycophenolate mofetil for graft-versus-host disease prophylaxis is associated with low non-relapse mortality.2025
  3. 3Post-transplant cyclophosphamide vs tacrolimus/methotrexate: Improved GRFS, reduced NRM, and less severe GVHD in myeloablative HLA-matched allogeneic transplantation2025
  4. 4Can we move beyond myeloablative conditioning (<scp>MAC</scp>)? A comparison of <scp>MAC</scp> versus reduced intensity conditioning (<scp>RIC</scp>) in patients aged younger than 65 years undergoing allogeneic haematopoietic cell transplantation using <scp>ATG</scp>‐<scp>PTCy</scp>‐<scp>CSA</scp> for <scp>GVHD</scp> prophylaxis2025 · 2 citations
  5. 5Impact of conditioning intensity on outcomes after unrelated donor hematopoietic cell transplantation using posttransplant cyclophosphamide-based GVHD prophylaxis2025