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September 10, 2025Frontiers in OncologyOpen Access

Conditioning regimens in pediatric myeloid malignancies undergoing allogeneic HSCT: a comparative single-center study

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Authors

AMAndra MarcuCJCristina JercanABAna Maria Bică

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Overview

Retrospective analysis compares overall survival and graft versus host disease in pediatric myeloid malignancies, suggesting benefits of reduced-toxicity conditioning.

Key Points

  • Reduced-toxicity conditioning showed faster platelet engraftment and shorter hospitalization, indicating a potential advantage.
  • While overall survival rates were not significantly different, children under 10 years old on RTC appeared to have a higher risk of relapse.
  • Viral reactivations were more common with RTC and RIC, but RTC demonstrated better viral control, particularly in clearing CMV.
  • A subgroup analysis identified clofarabine-based RTC regimens as having promising trends toward improved overall survival compared to fludarabine.

Cite This Study

Marcu et al. (2025) studied this question.

synapsesocial.com/papers/68c23b4ab210217d64783aaahttps://doi.org/10.3389/fonc.2025.1623636
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Conditioning intensity and post-transplant outcomes in acute myeloid leukemia: A real-world analysis.2026
  2. 2Outcomes of myeloablative vs reduced and non-myeloablative conditioning in MRD-negative AML and ALL with ptcy-based GVHD prophylaxis2025
  3. 3Impact of conditioning regimen on outcomes of adolescents and young adults AML patients undergoing HCT in complete remission, with transplant conditioning intensity score of 3.5-4.0. a study from the acute leukemia working party of the european society for blood and marrow transplantation.2025 · 1 citations
  4. 4Can we move beyond myeloablative conditioning (<scp>MAC</scp>)? A comparison of <scp>MAC</scp> versus reduced intensity conditioning (<scp>RIC</scp>) in patients aged younger than 65 years undergoing allogeneic haematopoietic cell transplantation using <scp>ATG</scp>‐<scp>PTCy</scp>‐<scp>CSA</scp> for <scp>GVHD</scp> prophylaxis2025 · 2 citations
  5. 5Expanding access in pediatrics: Outcomes of haploidentical transplantation with reduced intensity and peripheral blood stem cells2025